Development and application of reporter-expressing mononegaviruses: current challenges and perspectives.

@article{Falzarano2014DevelopmentAA,
  title={Development and application of reporter-expressing mononegaviruses: current challenges and perspectives.},
  author={Darryl Falzarano and Allison Groseth and Thomas Hoenen},
  journal={Antiviral research},
  year={2014},
  volume={103},
  pages={78-87}
}
Reverse genetics allows the generation of recombinant viruses entirely from cDNA. One application of this technology is the creation of reporter-expressing viruses, which greatly increase the detail and ease with which these viruses can be studied. However, there are a number of challenges when working with reporter-expressing viruses. Both the reporter protein itself as well as the genetic manipulations within the viral genome required for expression of this reporter can result in altered… CONTINUE READING

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