Corpus ID: 21993293

Development and application of a specific radioimmunoassay for trifluoperazine N4'-oxide to a kinetic study in humans.

@article{Aravagiri1986DevelopmentAA,
  title={Development and application of a specific radioimmunoassay for trifluoperazine N4'-oxide to a kinetic study in humans.},
  author={M. Aravagiri and E. Hawes and K. Midha},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1986},
  volume={237 2},
  pages={
          615-22
        }
}
A hapten derivative of prochlorperazine N4'-oxide, 7-(3-carboxy-propionyl)-prochlorperazine N4'-oxide, was synthesized and coupled to bovine serum albumin. Immunization of New Zealand White rabbits with this conjugate generated antibodies which were utilized to develop a radioimmunoassay (RIA) for the quantitation of trifluoperazine N4'-oxide (TFPNO). This assay enabled for the first time the quantitation of TFPNO in plasma, and 20 pg can be measured in a 200-microliter plasma sample with a… Expand
7 Citations