Development and application of a membrane cyclone reactor for in vivo NMR spectroscopy with high microbial cell densities.

@article{Hartbrich1996DevelopmentAA,
  title={Development and application of a membrane cyclone reactor for in vivo NMR spectroscopy with high microbial cell densities.},
  author={A Hartbrich and Gudrun Schmitz and Dirk Weuster-Botz and Albert A. de Graaf and Christian Wandrey},
  journal={Biotechnology and bioengineering},
  year={1996},
  volume={51 6},
  pages={624-35}
}
A new bioreactor system has been developed for in vivo NMR spectroscopy of microorganisms under defined physiological conditions. This cyclone reactor with an integrated NMR flow cell is continuously operated in the magnet of a 400-MHz wide-bore NMR spectrometer system. The residence times of medium and cells are decoupled by a circulation-integrated cross-flow microfiltration module to achieve higher cell densities as compared to continuous fermentations without cell retention (increase in… CONTINUE READING
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