Development and analytical performance of a new ARCHITECT automated dipeptidyl peptidase-4 immunoassay

@inproceedings{Hemken2017DevelopmentAA,
  title={Development and analytical performance of a new ARCHITECT automated dipeptidyl peptidase-4 immunoassay},
  author={Philip M. Hemken and Nicolette M. Jeanblanc and Tracey D Rae and Susan E. Brophy and Maria J. Datwyler and Ying Chun Xu and T. Scott Manetz and Inna Vainshtein and Meina Liang and Xiaodong Xiao and Partha S Chowdhury and Chien-ying Chang and Katie Streicher and Lydia M Greenlees and Koustubh Ranade and Gerard J. Davis},
  booktitle={Practical laboratory medicine},
  year={2017}
}
Background Dipeptidyl peptidase-4 (DPP-4) may be a suitable biomarker to identify people with severe asthma who have greater activation of the interleukin-13 (IL-13) pathway and may therefore benefit from IL-13-targeted treatments. We report the analytical performance of an Investigational Use Only immunoassay and provide data on the biological range of DPP-4 concentrations. Methods We assessed assay performance, utilising analyses of precision, linearity and sensitivity; interference from… CONTINUE READING