Development and Validation of an Enzyme Immunoassay for Fecal Dehydroepiandrosterone Sulfate in Japanese Macaques (Macaca fuscata)
@article{Takeshita2018DevelopmentAV, title={Development and Validation of an Enzyme Immunoassay for Fecal Dehydroepiandrosterone Sulfate in Japanese Macaques (Macaca fuscata)}, author={Rafaela S. C. Takeshita and Fred B. Bercovitch and Michael Alan Huffman and Kodzue Kinoshita}, journal={International Journal of Primatology}, year={2018}, volume={39}, pages={208-221} }
Measuring hormonal profiles is important in monitoring stress, physical fitness, and reproductive status in primates. Noninvasive methods have been used to measure several steroid hormones in primates without causing them stress. However, few studies have used feces or urine to measure dehydroepiandrosterone sulfate (DHEAS), an important precursor of sex steroids that has been studied as a biomarker of aging, pregnancy, and stress in humans and nonhuman primates. We developed an enzyme…
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References
SHOWING 1-10 OF 107 REFERENCES
The influence of age and season on fecal dehydroepiandrosterone-sulfate (DHEAS) concentrations in Japanese macaques (Macaca fuscata).
- BiologyGeneral and comparative endocrinology
- 2013
Comparison of different enzymeimmunoassays for assessment of adrenocortical activity in primates based on fecal analysis
- BiologyAmerican journal of primatology
- 2006
The data suggest that the reliability of a given fecal glucocorticoid assay in reflecting activity of the HPA axis in primates clearly depends on the species in question, and group‐specific assays have a high potential for cross‐species application.
Characterization of urinary and fecal metabolites of testosterone and their measurement for assessing gonadal endocrine function in male nonhuman primates.
- Biology, MedicineGeneral and comparative endocrinology
- 2002
Dehydroepiandrosterone sulfate levels reflect endogenous luteinizing hormone production and response to human chorionic gonadotropin challenge in older female macaque (Macaca fascicularis)
- Biology, MedicineMenopause
- 2013
A positive adrenal androgen response to LH/chorionic gonadotropin in older female higher primates is demonstrated and a mechanism for the rise in adrenalandrogen production during the menopausal transition in women is suggested.
Dehydroepiandrosterone-sulfate as a biomarker of senescence in male non-human primates
- Biology, MedicineExperimental Gerontology
- 2003
Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey
- Biology, MedicineThe Journal of Steroid Biochemistry and Molecular Biology
- 2002
ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism.
- Medicine, BiologyThe New England journal of medicine
- 1990
Environmental, biological, and social factors influencing fecal adrenal steroid concentrations in female Japanese macaques (Macaca fuscata)
- BiologyAmerican journal of primatology
- 2014
Results revealed that both fGC and fecal DHEAS concentrations are higher in females housed indoors in single cages than in those living outdoors in social groups, and fGC concentrations were higher in the cycling females during the mating season than the lactating females in the birth season.
Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.
- MedicineProceedings of the National Academy of Sciences of the United States of America
- 2000
A number of biological indices confirmed the lack of harmful consequences of this 50 mg/day DHEA administration over one year, indicating that this kind of replacement therapy normalized some effects of aging, but does not create "supermen/women" (doping).
Measuring Fecal Glucocorticoid Metabolites in Mammals and Birds: The Importance of Validation
- Biology, Environmental ScienceAnnals of the New York Academy of Sciences
- 2005
Comprehensive information on the animals' biology and stress physiology should be carefully taken into account to ensure that the measurement of fecal GCMs can be used as a powerful tool to assess adrenocortical activity in diverse investigations on laboratory, companion, farm, zoo, and wild animals.