Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.

@article{Demeestere2016DevelopmentAV,
  title={Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.},
  author={Delphine Demeestere and Eline Dejonckheere and Sophie Steeland and Paco Hulpiau and Jurgen Haustraete and Nick Devoogdt and Rielana Wichert and Christoph Becker-Pauly and Elien Van Wonterghem and Sylviane Dewaele and Griet Van Imschoot and Jeroen C.J.H Aerts and Lutgarde Arckens and Yvan Saeys and Claude Libert and Roosmarijn E. Vandenbroucke},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2016},
  volume={24 5},
  pages={890-902}
}
A detrimental role for matrix metalloproteinase 8 (MMP8) has been identified in several pathological conditions, e.g., lethal hepatitis and the systemic inflammatory response syndrome. Since matrix MMP8-deficient mice are protected in the above-mentioned diseases, specific MMP8 inhibitors could be of clinical value. However, targeting a specific matrix metalloproteinase remains challenging due to the strong structural homology of matrix metalloproteinases, which form a family of 25 members in… CONTINUE READING