Development and Validation of a RP-HPLC Method for Assay of Atorvastatin and its Application in Dissolution Studies on Thermosensitive Hydrogel-Based Nanocrystals

@inproceedings{Kurakula2014DevelopmentAV,
  title={Development and Validation of a RP-HPLC Method for Assay of Atorvastatin and its Application in Dissolution Studies on Thermosensitive Hydrogel-Based Nanocrystals},
  author={Mallesh Kurakula and Tariq Rashad Ali Sobahi and AM El-Helw and M. Abdelaal},
  year={2014}
}
Purpose: To develop and validate a novel reverse phase high performance liquid chromatographic (RP-HPLC) method for the quantification of atorvastatin in thermosensitive hydrogel-based nanocrystal formulation. Method: Chromatographic identification was achieved on C18 (5 μm) column using acetonitrile and 0.025 M potassium dihydrogen ortho-phosphate buffer pH 5 (45:55 v/v) as mobile phase, at a flow rate of 1.5 mL/min and using photo diode array detector (PDA) at 246 nm. The developed HPLC… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Antihyperlipidemic agents: Advances in research and application

QA Acton
Scholarly Editions, • 2012
View 1 Excerpt

Development and validation of a UV-spectrophotometric method for quantification of atorvastatin in tablets

S Ghanty, N Sadhukhan, A. Mondal
J. Pharma. Sci. Tech • 2012
View 1 Excerpt

Estimation of prednisolone in proliposomal formulation using RP -HPLC method

M Kurakula, AB Mohd, P Samhuidrom Rao, PV. Diwan
Int. J. Res. Pharm. Biomed. Sci • 2011
View 1 Excerpt

Stability-indicating RP-HPLC method for analysis of atorvastatin in bulk drug, marketed tablet and nanoemulsion formulation

G Mustafa, A Azeem, +3 authors S. Talegaonkar
J. Chil. Chem. Soc • 2010
View 2 Excerpts

HPLC methods for the determination of simvastatin and atorvastatin

L Novakova, D Satinsky, P. Solich
Trends Anal. Chem • 2008
View 1 Excerpt