Development and Validation of a HPLC-DAD Separation Method for Determination of Bioactive Antrocin in Medicinal Mushroom Antrodia Camphorata

  title={Development and Validation of a HPLC-DAD Separation Method for Determination of Bioactive Antrocin in Medicinal Mushroom Antrodia Camphorata},
  author={Madamanchi Geethangili and Yerra Koteswara Rao and Yew-Min Tzeng},
  journal={International Journal of Applied Science and Engineering},
Mushrooms are a food with high nutritional value. Antrodia camphorata (AC), is a medicinal mushroom being widely used as food dietary supplement for cancer prevention. The sesquiterpene lactone, antrocin reported as a novel dual Akt and mTOR inhibitor in metastatic breast cancer cells and, is the most potent among more than one hundred secondary metabolites isolated from AC. For the first time, this study developed and validated a simple high-performance liquid chromatography coupled with diode… Expand

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