Development and Validation of a Dried Blood Spot LC-MS/MS assay To Quantify Furosemide in Human Whole Blood: An Approach to Improve the Design of PK Studies in Pediatric Population

Abstract

Furosemide remains to be one of the most widely used therapies in pediatric and neonatal intensivecare and is a drug of choice in the long-term management of cardiac, pulmonary, and kidney diseases in children.Quantitation of furosemide in neonates and small children require the availability of highly sensitive assays in small volume of sample. Here, we… (More)

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