Development and Validation of Insulin-like Growth Factor-1 Score to Assess Hepatic Reserve in Hepatocellular Carcinoma

@inproceedings{Kaseb2014DevelopmentAV,
  title={Development and Validation of Insulin-like Growth Factor-1 Score to Assess Hepatic Reserve in Hepatocellular Carcinoma},
  author={Ahmed Kaseb and Lianchun Xiao and Manal M. Hassan and Young Kwang Chae and Ju-Seog Lee and J. Nicholas Vauthey and Sunil Krishnan and Sheree Cheung and Hesham M. Hassabo and Thomas A Aloia and Claudius Conrad and Steven A. Curley and John Moore Vierling and Prasun Kumar Jalal and K. Raghav and Michael T Wallace and Asif Rashid and James L Abbruzzese and Robert A. Wolff and Jeffrey S. Morris},
  booktitle={Journal of the National Cancer Institute},
  year={2014}
}
BACKGROUND Child-Turcotte-Pugh (CTP) score is the standard tool to assess hepatic reserve in hepatocellular carcinoma (HCC), and CTP-A is the classic group for active therapy. However, CTP stratification accuracy has been questioned. We hypothesized that plasma insulin-like growth factor 1 (IGF-1) is a valid surrogate for hepatic reserve to replace the subjective parameters in CTP score to improve its prognostic accuracy. METHODS We retrospectively tested plasma IGF-1 levels in the training… CONTINUE READING