Development and Physical Characterization of Sorbitan Monoester Niosomes for Insulin Oral Delivery

@article{Varshosaz2003DevelopmentAP,
  title={Development and Physical Characterization of Sorbitan Monoester Niosomes for Insulin Oral Delivery},
  author={Jaleh Varshosaz and Abbas Pardakhty and Valiollah Hajhashemi and Abdolhossein Rouholamini Najafabadi},
  journal={Drug Delivery},
  year={2003},
  volume={10},
  pages={251 - 262}
}
Niosomes of sorbitan monoesters (Span 20, 40, 60, and 80) were prepared using the film hydration method without sonication. Unlike the other surfactants, Span 80 did not form niosomes in the absence of a sufficient amount of cholesterol. The size of vesicles depended on the cholesterol molar ratio or charge incorporation. The amount of insulin released in simulated intestinal fluid from Span 40 and 60 was lower than Span 20 and 80 vesicles. Vesicles containing Span 60 showed the highest… Expand
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