Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine.

@article{Lungare2016DevelopmentAE,
  title={Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine.},
  author={Shital Lungare and James L. Bowen and Raj K S Badhan},
  journal={Journal of pharmaceutical sciences},
  year={2016},
  volume={105 3},
  pages={
          1209-20
        }
}
The aim of this study was to develop and characterize an intranasal delivery system for amantadine hydrochloride (AMT). Optimal formulations consisted of a thermosensitive polymer Pluronic® 127 and either carboxymethyl cellulose or chitosan which demonstrated gel transition at nasal cavity temperatures (34 ± 1°C). Rheologically, the loss tangent (Tan δ) confirmed a 3-stage gelation phenomena at 34 ± 1°C and non-Newtonian behavior. Storage of optimized formulation carboxymethyl cellulose and… CONTINUE READING
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