• Corpus ID: 55419328

Development and Evaluation of Transdermal Patches of Quetiapine fumerate for the treatment of psychosis

@article{Garud2013DevelopmentAE,
  title={Development and Evaluation of Transdermal Patches of Quetiapine fumerate for the treatment of psychosis},
  author={Akanksha Garud and Navneet Garud and Akanksha Namdeo},
  journal={International Journal of Drug Delivery},
  year={2013},
  volume={4},
  pages={470-476}
}
The aim of the present study was to formulate and evaluate the transdermal patches of an antipsychotic drug Quetiapine fumerate (QF) for the treatment of psychosis and schizophrenia. The transdermal patches was prepared by the solvent evaporation method using hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) in five different ratios 1:0, 2:1, 1:1, 1:2, 0:1. The PEG-400 and DMSO were used as plasticizers and permeation enhancer respectively to enhance the permeability of the drug… 
3 Citations

Figures and Tables from this paper

References

SHOWING 1-10 OF 25 REFERENCES
Design and evaluation of transdermal drug delivery of ketotifen fumarate
The purpose of this research work was to develop and evaluate matrix-type transdermal therapeutic system containing Ketotifen fumarate with different ratios of hydrophilic and hydrophobic polymeric
Development of Transdermal Patches of Nicardipine Hydrochloride: An Attempt to Improve Bioavailability
The purpose of this research work was to develop and evaluate matrix-type transdermal therapeutic system containing Nicardipine hydrochloride with different ratios of hydrophilic and hydrophobic
PREPARATION AND EVALUATION OF TRANSDERMAL PATCH OF DESLORATADINE
TLDR
Transdermal patches prepared by using film forming polymer such as HPMC 6 cps with PG as a plasticzer were found to be satisfactory in terms of physicochemical properties like appearance, thickness, weight variation, folding endurance, moisture content, tensile strength, percent elongation at break and percent drug content.
Formulation and evaluation of transdermal patch of Aceclofenac
The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Aceclofenac with different ratios of hydrophilic (hydroxyl propyl cellulose) and hydrophobic
Optimized preparation and evaluation of indomethacin transdermal patch
TLDR
The present data indicates the feasibility of developing indomethacin transdermal patches that showed good uniformity with regard to drug content and drug release.
An investigation into the transdermal delivery of nifedipine.
Development of domperidone bilayered matrix type transdermal patches: physicochemical, in vitro and ex vivo characterization
TLDR
Domperidone bilayered matrix type transdermal therapeutic systems could be prepared with the required flux and suitable mechanical properties and showed no evidence of interaction between the drug and polymers.
DESIGN, DEVELOPMENT AND EVALUATION OF MUCCOADHESIVE PATCHES OF NIFEDIPINE FOR BUCCAL DELIVERY
TLDR
The buccal region offers an attractive route of administration for systemic drug delivery and thus bypasses liver and avoids pre-systemic elimination in the GI tract and liver and a high bioavailability is obtained.
TRANSDERMAL DRUG DELIVERY SYSTEM: REVIEW
TLDR
Transdermal drug delivery is a recent technology which promises a great future it has a potential to limit the use of needles for administering wide variety of drugs but cost factor is a important thing to consider since developing nations like India have second highest population, but due to higher cost TDDS are the hidden part of therapy used in general population.
Quetiapine in the treatment of schizophrenia and related disorders
TLDR
The efficacy of quetiapine in reducing positive and negative symptoms of schizophrenia has been proven in several clinical trials with placebo-controlled comparators and has become well established in the treatment of schizophrenia and manic episodes.
...
1
2
3
...