Development and Evaluation of Ethyl Cellulose-Based Transdermal Films of Furosemide for Improved In Vitro Skin Permeation

@article{Patel2009DevelopmentAE,
  title={Development and Evaluation of Ethyl Cellulose-Based Transdermal Films of Furosemide for Improved In Vitro Skin Permeation},
  author={Dhaval P. Patel and Chitral Mallikarjuna Setty and Gaurav N. Mistry and Santnu L. Patel and Tarun J. Patel and Pritesh C. Mistry and Amar K. Rana and Pritesh Patel and Rishabh S. Mishra},
  journal={AAPS PharmSciTech},
  year={2009},
  volume={10},
  pages={437-442}
}
Transdermal films of the furosemide were developed employing ethyl cellulose and hydroxypropyl methylcellulose as film formers. The effect of binary mixture of polymers and penetration enhancers on physicochemical parameters including thickness, moisture content, moisture uptake, drug content, drug–polymer interaction, and in vitro permeation was evaluated. In vitro permeation study was conducted using human cadaver skin as penetration barrier in modified Keshary–Chein diffusion cell. In vitro… CONTINUE READING
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