Development and Characterization of a Severe Acute Respiratory Syndrome—Associated Coronavirus—Neutralizing Human Monoclonal Antibody That Provides Effective Immunoprophylaxis in Mice

@article{Greenough2005DevelopmentAC,
  title={Development and Characterization of a Severe Acute Respiratory Syndrome—Associated Coronavirus—Neutralizing Human Monoclonal Antibody That Provides Effective Immunoprophylaxis in Mice},
  author={T. Greenough and G. Babcock and A. Roberts and Hector Javier Hernandez and W. Thomas and Jennifer A. Coccia and R. Graziano and M. Srinivasan and I. Lowy and R. Finberg and K. Subbarao and L. Vogel and M. Somasundaran and K. Luzuriaga and J. Sullivan and D. Ambrosino},
  journal={The Journal of Infectious Diseases},
  year={2005},
  volume={191},
  pages={507 - 514}
}
  • T. Greenough, G. Babcock, +13 authors D. Ambrosino
  • Published 2005
  • Medicine, Biology
  • The Journal of Infectious Diseases
  • Abstract Background. Severe acute respiratory syndrome (SARS) remains a significant public health concern after the epidemic in 2003. Human monoclonal antibodies (MAbs) that neutralize SARS-associated coronavirus (SARSCoV) could provide protection for exposed individuals. Methods. Transgenic mice with human immunoglobulin genes were immunized with the recombinant major surface (S) glycoprotein ectodomain of SARS-CoV. Epitopes of 2 neutralizing MAbs derived from these mice were mapped and… CONTINUE READING
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