Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes.

@article{Beauchamp2015DevelopmentAC,
  title={Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes.},
  author={Philippe Beauchamp and Wolfgang Moritz and Jens Maria Kelm and Nina D. Ullrich and Irina Agarkova and Blake D. Anson and Thomas M. Suter and Christian Zuppinger},
  journal={Tissue engineering. Part C, Methods},
  year={2015},
  volume={21 8},
  pages={852-61}
}
Cardiomyocytes (CMs) are terminally differentiated cells in the adult heart, and ischemia and cardiotoxic compounds can lead to cell death and irreversible decline of cardiac function. As testing platforms, isolated organs and primary cells from rodents have been the standard in research and toxicology, but there is a need for better models that more… CONTINUE READING