Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

@article{Coler2011DevelopmentAC,
  title={Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant},
  author={R. Coler and S. Bertholet and M. Moutaftsi and Jeff Guderian and H. Windish and S. Baldwin and Elsa M. Laughlin and M. S. Duthie and Christopher B Fox and D. Carter and M. Friede and T. Vedvick and S. Reed},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
  • R. Coler, S. Bertholet, +10 authors S. Reed
  • Published 2011
  • Biology, Medicine
  • PLoS ONE
  • Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls, are driven by Toll-like receptor (TLR) 4 and adaptor proteins including MyD88 and TRIF, leading to the production of inflammatory cytokines, type I interferons, and chemokines. We report here on the characterization of a synthetic hexaacylated lipid A derivative, denoted as glucopyranosyl lipid adjuvant (GLA). We assessed the effects of GLA on murine and human… CONTINUE READING
    240 Citations

    Paper Mentions

    Interventional Clinical Trial
    The clinical trial phase 2b is designed to assess the safety and the specific immune response of the active ingredient (protein + adjuvant) in healthy and then in infected school… Expand
    ConditionsSchistosomiasis
    InterventionBiological, Drug
    Interventional Clinical Trial
    The clinical trial phase 2a is designed to assess the safety of the active ingredient (protein + adjuvant) and secondarily its immunogenicity in healthy male adults from 18 to 49… Expand
    ConditionsSchistosomiasis
    InterventionBiological, Drug
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