Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant
@article{Coler2011DevelopmentAC, title={Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant}, author={R. Coler and S. Bertholet and M. Moutaftsi and Jeff Guderian and H. Windish and S. Baldwin and Elsa M. Laughlin and M. S. Duthie and Christopher B Fox and D. Carter and M. Friede and T. Vedvick and S. Reed}, journal={PLoS ONE}, year={2011}, volume={6} }
Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls, are driven by Toll-like receptor (TLR) 4 and adaptor proteins including MyD88 and TRIF, leading to the production of inflammatory cytokines, type I interferons, and chemokines. We report here on the characterization of a synthetic hexaacylated lipid A derivative, denoted as glucopyranosyl lipid adjuvant (GLA). We assessed the effects of GLA on murine and human… CONTINUE READING
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Interventional Clinical Trial
The clinical trial phase 2b is designed to assess the safety and the specific immune response
of the active ingredient (protein + adjuvant) in healthy and then in infected school… Expand
Conditions | Schistosomiasis |
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Intervention | Biological, Drug |
Interventional Clinical Trial
The clinical trial phase 2a is designed to assess the safety of the active ingredient
(protein + adjuvant) and secondarily its immunogenicity in healthy male adults from 18 to 49… Expand
Conditions | Schistosomiasis |
---|---|
Intervention | Biological, Drug |
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