Development and Characterization of Human Cerebral Organoids: An Optimized Protocol.

Abstract

Studies of human neurodevelopmental disorders and stem cell-based regenerative transplants have been hampered by the lack of a model of the developing human brain. Stem cell-derived neurons suffer major limitations, including the ability to recapitulate the 3-dimensional architecture of a brain tissue and the representation of multiple layers and cell types… (More)
DOI: 10.1177/0963689717752946