Development and Characterization of Darbepoetin

  title={Development and Characterization of Darbepoetin},
  author={Joan C. Egrie and Jeffrey K. Browne},
Studies on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of the molecule and its serum half-life and in vivo biological activity, but an inverse relationship with its receptor-binding affinity. These observations led to the hypothesis that increasing the carbohydrate… CONTINUE READING