Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

@inproceedings{Weiss2014DevelopmentAB,
  title={Development and Bioorthogonal Activation of Palladium-Labile
Prodrugs of Gemcitabine},
  author={Jason T. Weiss and John C. Dawson and Craig Fraser and Witold Rybski and Carmen Torres-S{\'a}nchez and Mark Bradley and E Elizabeth Patton and Neil Oliver Carragher and Asier Unciti-Broceta},
  booktitle={Journal of medicinal chemistry},
  year={2014}
}
Bioorthogonal chemistry has become one of the main driving forces in current chemical biology, inspiring the search for novel biocompatible chemospecific reactions for the past decade. Alongside the well-established labeling strategies that originated the bioorthogonal paradigm, we have recently proposed the use of heterogeneous palladium chemistry and bioorthogonal Pd(0)-labile prodrugs to develop spatially targeted therapies. Herein, we report the generation of biologically inert precursors… CONTINUE READING
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