Development and Application of an Isolated Perfused Rat Liver Model to Study the Stimulation and Inhibition of Tumor Necrosis Factor-α Production ex Vivo

Abstract

Purpose. To develop an isolated perfused rat liver (IPRL) model with low baseline levels of tumor necrosis factor (TNF)-α in the outlet perfusate to study the effects of immunostimulants and immunosuppressants on the release of TNF-α from this organ. Methods. Isolated rat livers were perfused with a buffer containing no albumin or three different bovine… (More)
DOI: 10.1023/A:1013603331899

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