Development: Ubiquitin tag for sperm mitochondria

  title={Development: Ubiquitin tag for sperm mitochondria},
  author={Peter Sutovsky and Ricardo D Moreno and Jo{\~a}o Ramalho‐Santos and Tanja Dominko and Calvin R. Simerly and Gerald Schatten},
Like other mammals, humans inherit mitochondria from the mother only, even though the sperm contributes nearly one hundred mitochondria to the fertilized egg. In support of the idea that this strictly maternal inheritance of mitochondrial DNA arises from the selective destruction of sperm mitochondria, we show here that sperm mitochondria inside fertilized cow and monkey eggs are tagged by the recycling marker protein ubiquitin. This imprint is a death sentence that is written during… 

Barriers to male transmission of mitochondrial DNA in sperm development.

Inheriting Maternal mtDNA

Sperm mitochondria are destroyed by autophagy at fertilization in C. elegans, explaining the maternal origin of mitochondria in this and perhaps other animals. In almost all eukaryotes, mitochondrial

Sperm mitochondria in reproduction: good or bad and where do they go?

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

It is shown that, upon fertilization, a Caenorhabditis elegans spermatozoon triggers the recruitment of autophagosomes within minutes and subsequent paternal mitochondria degradation, which suggests that this autophagy event is evolutionarily conserved to prevent both the transmission of paternal mitochondrial DNA to the offspring and the establishment of heteroplasmy.

Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans

It is reported that this paternal mitochondrial elimination process is conserved in Caenorhabditis elegans, and that the lysosomal pathway actively participates in this process.

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

It is shown that autophagy, which delivers cytosolic components to lysosomes for degradation, is required for the elimination of paternal mitochondria in Caenorhabditis elegans and thereby maternal inheritance of mitochondrial DNA.

Autophagosomal Sperm Organelle Clearance and mtDNA Inheritance in C. elegans.

This chapter will review the knowledge acquired on sperm inherited organelles clearance during the recent years using C. elegans to study the mechanisms underlying mitochondrial DNA maternal inheritance and paternal components sorting.

Active digestion of sperm mitochondrial DNA in single living sperm revealed by optical tweezers

This investigation visualized mt nucleoids in living sperm by using highly sensitive SYBR green I vital staining and clarified that the elimination of sperm mtDNA upon fertilization is achieved through two steps: gradual decrease of mt nucleoid numbers during spermatogenesis and rapid digestion just after fertilization.



The fate of sperm middle-piece mitochondria in the rat egg.

All mitochondria found in the developing rat embryo may originate from the egg, as the swelling of the male mitochondrial elements becomes more extreme during the cleavage divisions, and they finally seem to disintegrate.

Maternal inheritance of mammalian mitochondrial DNA

Evidence is presented that the mitochondrial genome is inherited maternally in mammals too, unlike chromosomal genes, which are inherited biparentally.

Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis.

It is concluded that cytoplasmic genomes are transmitted uniparentally in intraspecific crosses in mammals as in Chlamydomonas and that leakage of parental mtDNA is limited to interspecific crosses, which rarely occur in nature.

Paternal inheritance of mitochondrial DNA in mice

Paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10−4, relative to the maternal contributions, which provides a mechanism for generating heteroplasmy and may explain mitochondrial disorders exhibiting biparental transmission.

Fate of the sperm mitochondria, and the incorporation, conversion, and disassembly of the sperm tail structures during bovine fertilization.

The data suggest that the disassembly of the sperm tail during bovine fertilization occurs as a series of precisely orchestrated events involving the destruction and transformation of particular sperm structures into zygotic and embryonic components.

A Role for Ubiquitination in Mitochondrial Inheritance in Saccharomyces cerevisiae

The smm1 mutation suppresses defects in mitochondrial distribution and morphology caused by the mdm1-252 mutation in the yeast Saccharomyces cerevisiae, and site-directed mutagenesis reveals a novel function for protein ubiquitination.

Maternal inheritance of human mitochondrial DNA.

The results of this study demonstrate that human mitochondrial DNA is maternally inherited and represents a convenient way to obtain data on mitochondrial DNA variation in both individuals and populations.

Expression of prohibitin in rat seminiferous epithelium.

The expression pattern of the prohibitin gene in rat testis appears to correlate with a proposed antiproliferative role of prohibitin, which is expressed differentially in testis.