Development: Ubiquitin tag for sperm mitochondria

@article{Sutovsky1999DevelopmentUT,
  title={Development: Ubiquitin tag for sperm mitochondria},
  author={P. Sutovsky and R. Moreno and J. Ramalho-Santos and T. Dominko and C. Simerly and G. Schatten},
  journal={Nature},
  year={1999},
  volume={402},
  pages={371-372}
}
  • P. Sutovsky, R. Moreno, +3 authors G. Schatten
  • Published 1999
  • Biology, Medicine
  • Nature
  • Like other mammals, humans inherit mitochondria from the mother only, even though the sperm contributes nearly one hundred mitochondria to the fertilized egg. In support of the idea that this strictly maternal inheritance of mitochondrial DNA arises from the selective destruction of sperm mitochondria, we show here that sperm mitochondria inside fertilized cow and monkey eggs are tagged by the recycling marker protein ubiquitin. This imprint is a death sentence that is written during… CONTINUE READING
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