Development/Plasticity/Repair Ca Influx through Mechanosensitive Channels Inhibits Neurite Outgrowth in Opposition to Other Influx Pathways and Release from Intracellular Stores

Abstract

Ca 2 signals are known to be important regulators of neurite outgrowth and steering. Here we show that inhibiting Ca 2 influx through stretch-activated channels using various compounds, including a highly specific peptide isolated from Grammostola spatulata spider venom (GsMTx4), strongly accelerates the rate of neurite extension on diverse substrata and… (More)

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