Corpus ID: 20657140

Development, validation and implementation of an in vitro model for the study of metabolic and immune function in normal and inflamed human colonic epithelium.

@article{Pedersen2015DevelopmentVA,
  title={Development, validation and implementation of an in vitro model for the study of metabolic and immune function in normal and inflamed human colonic epithelium.},
  author={G. Pedersen},
  journal={Danish medical journal},
  year={2015},
  volume={62 1},
  pages={
          B4973
        }
}
  • G. Pedersen
  • Published 2015
  • Medicine
  • Danish medical journal
  • Ulcerative colitis (UC) and Crohn's disease (CD), collectively referred to as inflammatory bowel disease (IBD), are chronic immune disorders affecting the gastrointestinal tract. The aetiology of IBD remains an enigma, but increasing evidence suggests that the development of IBD may be triggered by a disturbance in the balance between gut commensal bacteria and host response in the intestinal mucosa. It is now known that epithelial cells have the capacity to secrete and respond to a range of… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 263 REFERENCES
    Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease
    • 105
    • Highly Influential
    Inflammation in the Intestinal Tract: Pathogenesis and Treatment
    • 74
    • Highly Influential
    • PDF
    Is metabolic stress a common denominator in inflammatory bowel disease?
    • 21
    • Highly Influential
    Role of cytokines in inflammatory bowel disease.
    • 439
    • PDF
    Role of cytokines in the pathogenesis of inflammatory bowel disease.
    • 645
    Epithelia under metabolic stress perceive commensal bacteria as a threat.
    • 148
    Colonic epithelium is diffusely abnormal in ulcerative colitis and colorectal cancer.
    • 40
    • PDF