Development, optimization and characterization of a full-thickness tissue engineered human oral mucosal model for biological assessment of dental biomaterials.

@article{Moharamzadeh2008DevelopmentOA,
  title={Development, optimization and characterization of a full-thickness tissue engineered human oral mucosal model for biological assessment of dental biomaterials.},
  author={Keyvan Moharamzadeh and Ian Michael Brook and Richard van Noort and Andy M. Scutt and Keith V. Smith and Martin H. Thornhill},
  journal={Journal of materials science. Materials in medicine},
  year={2008},
  volume={19 4},
  pages={1793-801}
}
Restorative dental materials and oral health care products come into direct contact with oral mucosa and can cause adverse reactions. In order to obtain an accurate risk assessment, the in vitro test model must reflect the clinical situation as closely as possible. The aim of this study was to develop and optimize a three-dimensional full-thickness engineered human oral mucosal model, which can be used for biological assessment of dental materials. In this study human oral fibroblasts and… CONTINUE READING