Development, characterization and in vivo evaluation of benzocaine-loaded liposomes.

@article{Mura2007DevelopmentCA,
  title={Development, characterization and in vivo evaluation of benzocaine-loaded liposomes.},
  author={P. Mura and F. Maestrelli and M. L. Gonz{\'a}lez-Rodr{\'i}guez and Ilaria Michelacci and C. Ghelardini and A. Rabasco},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2007},
  volume={67 1},
  pages={
          86-95
        }
}
  • P. Mura, F. Maestrelli, +3 authors A. Rabasco
  • Published 2007
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
This study reports the development and in vivo evaluation of a liposomal formulation of the local anaesthetic benzocaine. Multi-lamellar (MLV) and small uni-lamellar (SUV) vesicles entrapping benzocaine were prepared using 50:50 w/w phosphatidylcholine-cholesterol as lipophilic phase and 50:50 v/v ethanol-water as hydrophilic phase. Liposome size, Zeta-potential, encapsulation efficiency and skin penetration properties were determined. Drug permeation from liposomal dispersions, as such or… Expand
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