Development, characterization, and anti-microbial efficacy of hydroxyapatite-chlorhexidine coatings produced by surface-induced mineralization.

@article{Campbell2000DevelopmentCA,
  title={Development, characterization, and anti-microbial efficacy of hydroxyapatite-chlorhexidine coatings produced by surface-induced mineralization.},
  author={Allison A Campbell and Li Song and Xiaohong Shari Li and By JoAnne Nelson and Carolina Bottoni and Donald Elliott Brooks and E Schuyler Dejong},
  journal={Journal of biomedical materials research},
  year={2000},
  volume={53 4},
  pages={400-7}
}
The surface-induced mineralization (SIM) technique was used to produce hydroxyapatite (HAP) coatings on external fixation pins with the antimicrobial agent, chlorhexidine, incorporated within the coating. The SIM process involved surface modification of the substrate with organic functional groups followed by immersion in aqueous supersaturated calcium phosphate solutions. X-ray diffraction spectra confirmed that hydroxyapatite coatings were formed. Chlorhexidine was incorporated into the… CONTINUE READING