Developing strategies for isolation of minor impurities with mass spectrometry-directed fractionation.

@article{Niessen2002DevelopingSF,
  title={Developing strategies for isolation of minor impurities with mass spectrometry-directed fractionation.},
  author={Wilfried M. A. Niessen and Jing Lin and G{\'e}rard C Bondoux},
  journal={Journal of chromatography. A},
  year={2002},
  volume={970 1-2},
  pages={131-40}
}
Efficient and automated purification of new chemical entities/potential drug substances and isolation of minor impurities are important aspects of early drug discovery and development strategies, especially when combinatorial synthesis is applied. LC-MS controlled preparative LC and automated fraction collection have been developed for this purpose. The… CONTINUE READING