Developing prosthetics to treat cognitive disabilities resulting from acquired brain injuries
@article{Schiff2002DevelopingPT, title={Developing prosthetics to treat cognitive disabilities resulting from acquired brain injuries}, author={Nicholas D. Schiff and Fred Plum and Ali R. Rezai}, journal={Neurological Research}, year={2002}, volume={24}, pages={116 - 124} }
Abstract Persistent cognitive disabilities represent the most troublesome consequences of acquired brain injury. Although these problems are widely recognized, few neuroprosthetic efforts have focused on developing therapeutic strategies aimed at improving general cognitive functions such as sustained attention, intention, working memory or awareness. If possible, effective modulation of these neuropsychologic components might improve recovery of interactive behaviors. The emerging field of…
51 Citations
Central Thalamic Deep‐Brain Stimulation in the Severely Injured Brain
- Psychology, BiologyAnnals of the New York Academy of Sciences
- 2009
The scientific rationale supporting the potential use of deep‐brain electrical stimulation in the central thalamus as a method to improve behavioral responsiveness following severe brain injury is outlined.
Central thalamic deep brain stimulation for cognitive neuromodulation – a review of proposed mechanisms and investigational studies
- PsychologyThe European journal of neuroscience
- 2010
It is concluded that CT/DBS should be studied as a therapeutic intervention to improve impaired cognitive function in severely brain‐injured patients who, in addition to demonstrating clinical evidence of consciousness and goal‐directed behavior, retain sufficient preservation of large‐scale cerebral networks within the anterior forebrain.
How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs?
- Medicine, PsychologyCurrent opinion in neurology
- 2006
Purpose of reviewWe discuss the problems of evidence-based neurorehabilitation in disorders of consciousness, and recent functional neuroimaging data obtained in the vegetative state and minimally…
Towards a neurophysiological foundation for cognitive neuromodulation through deep brain stimulation
- Medicine, Psychology
- 2002
Modeling the minimally conscious state: measurements of brain function and therapeutic possibilities.
- Psychology, BiologyProgress in brain research
- 2005
Mechanisms and the Current State of Deep Brain Stimulation in Neuropsychiatry
- Psychology, MedicineCNS Spectrums
- 2003
Deep brain stimulation precisely targets neuroanatomical targets deep within the brain that are proposed to be centrally involved in the pathophysiology of some neuropsychiatric illnesses, offering the advantages of reversibility and adjustability.
Deep brain stimulation and cognition: moving from animal to patient
- Biology, PsychologyCurrent opinion in neurology
- 2007
This area of research offers the promise of new avenues to engage patients with nonprogressive brain injuries who, at present, have rather limited therapeutic options and will require careful attention to issues of research and clinical ethics and study design.
Deep Brain Stimulation in Depression: Background, Progress, and Key Issues
- Medicine, Psychology
- 2008
Deep brain stimulation is an approved adjunct therapy for severe, medication-refractory movement disorders, though it is currently investigational in neuropsychiatry and other neurological conditions and understanding the mechanism of action constitutes the current focus of a number of clinical and preclinical laboratories.
References
SHOWING 1-10 OF 95 REFERENCES
A neuromodulation strategy for rational therapy of complex brain injury states
- Psychology, BiologyNeurological research
- 2000
An innovative strategy for patient and target selection for neuromodulation of impaired cognitive function is outlined and scientific and ethical issues that will attend future efforts to appropriately risk-stratify patients and initiate interventions with therapeutic intent are considered.
Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain.
- Biology, MedicineBrain : a journal of neurology
- 2002
The variations in cerebral metabolism in chronic PVS patients indicate that some cerebral regions can retain partial function in catastrophically injured brains.
[Electrophysiological development under thalamic stimulation of post-traumatic persistent vegetative states. Apropos of 25 cases].
- Biology, MedicineNeuro-Chirurgie
- 1993
Changes such as long-term quantitative EEG as well as evoked potentials mostly precede clinical progress when present, and the proposal of "waking targeted" stimulations at the most favorable moments of the nyctohemeral period is proposed.
Rehabilitation of persons with traumatic brain injury.
- Medicine, PsychologyNIH consensus statement
- 1998
This statement provides state-of-the-art information regarding effective rehabilitation measures for persons who have suffered a traumatic brain injury (TBI) and presents the conclusions and recommendations of the consensus panel regarding these issues.
Does vestibular stimulation activate thalamocortical mechanisms that reintegrate impaired cortical regions?
- Psychology, MedicineProceedings of the Royal Society of London. Series B: Biological Sciences
- 1999
Transient improvements in impaired sensory, motor, linguistic and cognitive function developed within 30 s following application of the caloric stimulus and onset of horizontal nystagmus in an 81–year–old woman with an acute left cerebral hemisphere stroke.
The neuropathology of the vegetative state after an acute brain insult.
- Medicine, BiologyBrain : a journal of neurology
- 2000
A detailed neuropathological study of the brains of 49 patients who remained vegetative until death, 1 month to 8 years after an acute brain insult, finds profound damage to the subcortical white matter or to the major relay nuclei of the thalamus renders any structurally intact cortex unable to function.
Mechanisms of deep brain stimulation and future technical developments
- BiologyNeurological research
- 2000
Computer simulations suggest that irregular activity in neurons converging with other neurons can result in a loss of information transfer, and it is hypothesized that low frequency activity; either spontaneous or stimulated, could account for involuntary movements, including tremor.
Neuropathology in vegetative and severely disabled patients after head injury
- Medicine, PsychologyNeurology
- 2001
If the neuropathology differs in head-injured patients who were in a vegetative state (VS) or were severely disabled at time of death, half the severely disabled cases had only focal brain damage, a feature not found in any VS cases.
A proposed ethical framework for interventional cognitive neuroscience: A consideration of deep brain stimulation impaired consciousness
- Psychology, MedicineNeurological research
- 2000
An ethical framework for clinical research in interventional cognitive neuroscience is advanced and deep brain stimulation in traumatic brain injury is considered as a paradigm case to examine ethical obligations in human subject research.
A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor.
- Medicine, PsychologyThe New England journal of medicine
- 2000
Thalamic stimulation and thalamotomy are equally effective for the suppression of drug-resistant tremor, but thalamicstimulation has fewer adverse effects and results in a greater improvement in function.