Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

@article{Oppenheim1995DevelopingMN,
  title={Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF},
  author={Ronald W. Oppenheim and Lucien J. Houenou and James E. Johnson and L H Lin and Linxi Li and Albert C. Lo and Ann L. Newsome and David M. Prevette and Siwei Wang},
  journal={Nature},
  year={1995},
  volume={373},
  pages={344-346}
}
DURING normal development of the vertebrate nervous system, large numbers of neurons in the central and peripheral nervous system undergo naturally occurring cell death1. For example, about half of all spinal motor neurons die over a period of a few days in developing avian, rat and mouse embryos1. Previous studies have shown that extracts from muscle and brain, secreted factors from glia, as well as several growth factors and neurotrophic agents, including muscle-derived factors, can promote… CONTINUE READING
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