Developing clinical trials in stroke.

@article{Schwab2011DevelopingCT,
  title={Developing clinical trials in stroke.},
  author={S. Prexler Schwab and Patrick D. Lyden and Rainer Kollmar},
  journal={Therapeutic hypothermia and temperature management},
  year={2011},
  volume={1 4},
  pages={
          175-8
        }
}
Therapeutic hypothermia has been investigated experimentally in many models of cerebral ischemia and stroke. In rodent models of global forebrain ischemia, for example, mild variations in intraischemic brain temperature were first to influence critically the vulnerability of CA1 neurons in the hippocampus. These pioneering studies led to the realization that brain temperature played a critical role in determining the vulnerability of neuronal populations during transient periods of ischemia… CONTINUE READING
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