Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets.

@article{Munro2009DevelopingAB,
  title={Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets.},
  author={G. Munro and P. Ahring and N. Mirza},
  journal={Trends in pharmacological sciences},
  year={2009},
  volume={30 9},
  pages={
          453-9
        }
}
The use of genetically-engineered mice has identified alpha2- and alpha3-subunit containing GABA(A) receptors as principal contributors to the spinal disinhibition that occurs after inflammation and neuropathic injury. Pharmacological comparison of subtype selective allosteric modulators such as NS11394 and L838417 with either non-selective or full GABA(A) receptor modulators indicates that in addition to involvement of specific subunits per se, the level of efficacy at individual alpha… Expand
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