Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization.

@article{Guth2004DevelopingAS,
  title={Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization.},
  author={Brian D. Guth and Sabine Germeyer and Willi Kolb and Michael Markert},
  journal={Journal of pharmacological and toxicological methods},
  year={2004},
  volume={49 3},
  pages={159-69}
}
The aspects for developing a strategy for the preclinical testing of drug candidates for proarrhythmic potential are presented. The rationale for such a strategy reflects primarily the needs for efficient and scientifically based drug development and also attempts to anticipate the possible outcomes of the currently ongoing regulatory activity (ICH S7b and E14). Whereas a wealth of new data have emerged over the past few years, demonstrating the utility of test systems for detecting drug… CONTINUE READING

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