Developing a predictive signature for two trial endpoints using the cross-validated risk scores method.

  title={Developing a predictive signature for two trial endpoints using the cross-validated risk scores method.},
  author={Svetlana Cherlin and James M. S. Wason},
The existing cross-validated risk scores (CVRS) design has been proposed for developing and testing the efficacy of a treatment in a high-efficacy patient group (the sensitive group) using high-dimensional data (such as genetic data). The design is based on computing a risk score for each patient and dividing them into clusters using a nonparametric clustering procedure. In some settings, it is desirable to consider the tradeoff between two outcomes, such as efficacy and toxicity, or cost and… 
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