Developing HSCs become Notch independent by the end of maturation in the AGM region.

Abstract

The first definitive hematopoietic stem cells (dHSCs) in the mouse emerge in the dorsal aorta of the embryonic day (E) 10.5 to 11 aorta-gonad-mesonephros (AGM) region. Notch signaling is essential for early HSC development but is dispensable for the maintenance of adult bone marrow HSCs. How Notch signaling regulates HSC formation in the embryo is poorly… (More)
DOI: 10.1182/blood-2016-03-708164

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@article{Souilhol2016DevelopingHB, title={Developing HSCs become Notch independent by the end of maturation in the AGM region.}, author={C{\'e}line Souilhol and Javier G. Lend{\'i}nez and Stanislav Rybtsov and Fiona Murphy and Heather L Wilson and David Hills and Antoniana Batsivari and Anah{\'i} Binagui-Casas and Alison C McGarvey and Heather R Macdonald and Ryoichiro Kageyama and Christian W Siebel and Suling Zhao and Alexander B. Medvinsky}, journal={Blood}, year={2016}, volume={128 12}, pages={1567-77} }