Devazepide antagonizes the inhibitory effect of cholecystokinin on intake in sham-feeding rats.

@article{Melville1992DevazepideAT,
  title={Devazepide antagonizes the inhibitory effect of cholecystokinin on intake in sham-feeding rats.},
  author={Laura Diane Melville and Gerard P. Smith and James Gibbs},
  journal={Pharmacology, biochemistry, and behavior},
  year={1992},
  volume={43 3},
  pages={975-7}
}
3S(-)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-yl) -1H-indole-2-carboxamide (devazepide), a potent and selective cholecystokininA (CCKA) antagonist, has been shown to reverse the inhibitory effect of exogenously administered CCK-8 on food intake. In all tests, however, the inhibition of food intake could have been due not only to the CCK-8 administered but also to synergistic interactions between administered CCK-8 and endogenous satiety signals, such as glucagon or CCK… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors.

American journal of physiology. Regulatory, integrative and comparative physiology • 2007
View 4 Excerpts
Highly Influenced

Neuroendocrine control of satiation.

Hormone molecular biology and clinical investigation • 2014

CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats.

American journal of physiology. Regulatory, integrative and comparative physiology • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…