Deuterium Medicinal Chemistry: A New Approach to Drug Discovery and Development Vice President Drug Discovery and Basic Research

@inproceedings{Harbeson2014DeuteriumMC,
  title={Deuterium Medicinal Chemistry: A New Approach to Drug Discovery and Development Vice President Drug Discovery and Basic Research},
  author={Scott L. Harbeson},
  year={2014}
}
Selective replacement of hydrogen atoms with deuterium (deuteration) has the unique benefit of retaining the pharmacologic profile of physiologically active compounds while, in certain instances, positively impacting their metabolic fate. In these favorable cases, deuterium substitution can in principle improve the safety, efficacy, and/or tolerability of a therapeutic agent. Selective deuteration of compounds such as approved drugs with welldefined human pharmacological effects can potentially… CONTINUE READING

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