Deuterated protein folds obtained directly from unassigned nuclear overhauser effect data.

Abstract

We demonstrate the feasibility of determining the global fold of a highly deuterated protein from unassigned experimental NMR nuclear Overhauser effect (NOE) data only. The method relies on the calculation of a spatial configuration of covalently unconnected protons-a "cloud"-directly from unassigned distance restraints derived from 13C- and 15N-edited… (More)
DOI: 10.1021/ja074836e

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Cite this paper

@article{Bermejo2008DeuteratedPF, title={Deuterated protein folds obtained directly from unassigned nuclear overhauser effect data.}, author={Guillermo A Bermejo and Miguel Llin{\'a}s}, journal={Journal of the American Chemical Society}, year={2008}, volume={130 12}, pages={3797-805} }