Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Abstract

PTEN is one of the most frequently mutated tumour suppressors and reduction in PTEN protein stability also plays a role in tumorigenesis. Although several ubiquitin ligases for PTEN have been identified, the deubiquitylase for de-polyubiquitylation and stabilization of PTEN is less defined. Here, we report OTUD3 as a deubiquitylase of PTEN. OTUD3 interacts… (More)
DOI: 10.1038/ncb3218

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