Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

@article{Li2002DeubiquitinationOP,
  title={Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization},
  author={M. Li and D. Chen and Ariel Shiloh and J. Luo and A. Y. Nikolaev and Jun Qin and W. Gu},
  journal={Nature},
  year={2002},
  volume={416},
  pages={648-653}
}
  • M. Li, D. Chen, +4 authors W. Gu
  • Published 2002
  • Chemistry, Medicine
  • Nature
  • The p53 tumour suppressor is a short-lived protein that is maintained at low levels in normal cells by Mdm2-mediated ubiquitination and subsequent proteolysis. Stabilization of p53 is crucial for its tumour suppressor function. However, the precise mechanism by which ubiquitinated p53 levels are regulated in vivo is not completely understood. By mass spectrometry of affinity-purified p53-associated factors, we have identified herpesvirus-associated ubiquitin-specific protease (HAUSP) as a novel… CONTINUE READING
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    References

    SHOWING 1-10 OF 64 REFERENCES
    Regulation of p53 stability by Mdm2
    • 3,149
    Stress Signals Utilize Multiple Pathways To Stabilize p53
    • 381
    • PDF
    Mdm2 promotes the rapid degradation of p53
    • 4,004
    Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation
    • 398
    • PDF
    Functions of the MDM2 oncoprotein
    • 507
    Regulation of p53 Function and Stability by Phosphorylation
    • 442
    • PDF
    Synergistic activation of transcription by CBP and p53
    • 627