Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

  title={Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling},
  author={Hye Seung Jung and B-G Kim and Wei-dong Han and Jaehyeon Lee and J-Y Cho and W S Park and Madelon M Maurice and J-K Han and Min Jae Lee and Daniel Finley and E-h Jho},
Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl. Mutations in the RDU resulted in accumulation of polyubiquitinated forms of Dvl, which were mainly K63 linked. Small interfering RNA-based screening identified Usp14 as a mediator of Dvl deubiquitination. Genetic and chemical suppression of Usp14 activity caused an increase in Dvl… CONTINUE READING
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