Deubiquitination and Activation of AMPK by USP10.

@article{Deng2016DeubiquitinationAA,
  title={Deubiquitination and Activation of AMPK by USP10.},
  author={Min Deng and Xu Yang and B. W. Qin and Tongzheng Liu and Haoxing Zhang and Wei Guo and Seung Baek Lee and Jung Jin Kim and Jian Yuan and Huadong Pei and Liewei Wang and Zhenkun Lou},
  journal={Molecular cell},
  year={2016},
  volume={61 4},
  pages={614-624}
}
The AMP-activated protein kinase (AMPK) is the master regulator of metabolic homeostasis by sensing cellular energy status. When intracellular ATP levels decrease during energy stress, AMPK is initially activated through AMP or ADP binding and phosphorylation of a threonine residue (Thr-172) within the activation loop of its kinase domain. Here we report a key molecular mechanism by which AMPK activation is amplified under energy stress. We found that ubiquitination on AMPKα blocks AMPK… CONTINUE READING

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