Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

@article{Clementz2010DeubiquitinatingAI,
  title={Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.},
  author={Mark Anthony Clementz and Zhongbin Chen and Bridget S Banach and Yanhua Wang and Li Sun and Kiira M. Ratia and Yahira M. B{\'a}ez-Santos and Jie Wang and Jun Takayama and Arun K. Ghosh and K. M. G. Li and Andrew D. Mesecar and Susan C Baker},
  journal={Journal of virology},
  year={2010},
  volume={84 9},
  pages={
          4619-29
        }
}
Coronaviruses encode multifunctional proteins that are critical for viral replication and for blocking the innate immune response to viral infection. One such multifunctional domain is the coronavirus papain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB) activity, and antagonizes the induction of type I interferon (IFN). Here we characterized the DUB and IFN antagonism activities of the PLP domains of human coronavirus NL63 and severe acute… CONTINUE READING

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