Deubiquitinases Sharpen Substrate Discrimination during Membrane Protein Degradation from the ER

@inproceedings{Zhang2013DeubiquitinasesSS,
  title={Deubiquitinases Sharpen Substrate Discrimination during Membrane Protein Degradation from the ER},
  author={Zai-rong Zhang and Juan S Bonifacino and Ramanujan S Hegde},
  booktitle={Cell},
  year={2013}
}
Newly synthesized membrane proteins are queried by ubiquitin ligase complexes and triaged between degradative and nondegradative fates. The mechanisms that convert modest differences in substrate-ligase interactions into decisive outcomes of ubiquitination are not well understood. Here, we reconstitute membrane protein recognition and ubiquitination in liposomes using purified components from a viral-mediated degradation pathway. We find that substrate-ligase interactions in the membrane… CONTINUE READING
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