Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

@inproceedings{Kerr2015DetyrosinatedMM,
  title={Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle},
  author={Jaclyn P. Kerr and Patrick Robison and Guoli Shi and Alexey I. Bogush and Aaron M. Kempema and Joseph K. Hexum and Natalia Margarita Cediel Becerra and Daniel A Harki and Stuart S. Martin and Roberto Raiteri and Benjamin L Prosser and Christopher W Ward},
  booktitle={Nature communications},
  year={2015}
}
In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca(2+) signalling in healthy muscle, but in diseases such as Duchenne muscular dystrophy (DMD), microtubule alterations drive elevated X-ROS, disrupting Ca(2+) homeostasis and impairing function. Here we show that detyrosination, a post-translational modification of α-tubulin, influences X-ROS signalling, contraction speed and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

Misplaced Golgi Elements Produce Randomly Oriented Microtubules and Aberrant Cortical Arrays of Microtubules in Dystrophic Skeletal Muscle Fibers

Sarah Oddoux, Davide Randazzo, +3 authors Evelyn Ralston
  • Front. Cell Dev. Biol.
  • 2019
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 81 REFERENCES

Microtubule binding distinguishes dystrophin from utrophin.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2014