Detrusor smooth muscle cells of the guinea-pig are functionally coupled via gap junctions in situ and in cell culture

@article{Neuhaus2002DetrusorSM,
  title={Detrusor smooth muscle cells of the guinea-pig are functionally coupled via gap junctions in situ and in cell culture},
  author={Jochen Neuhaus and Hartwig Wolburg and Thomas Hermsdorf and Jens-Uwe Stolzenburg and Wolfgang Dorschner},
  journal={Cell and Tissue Research},
  year={2002},
  volume={309},
  pages={301-311}
}
Intercellular communication between smooth muscle cells is crucial for contractile behaviour in normal and pathologically altered urinary bladder. Since the study of coupling is difficult in situ, we established cell cultures of bladder smooth muscle cells to analyse coupling mechanisms. Microinjection of Lucifer yellow demonstrated syncytia composed of only a few to several dozen cells. Electron-microscopic examination of freeze-fracture specimens and ultrathin sections revealed that the dye… CONTINUE READING

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Structure and function of the bladder neck

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