Detrimental effects of nicotine on the acute gastric mucosal injury induced by ethanol: role of asymmetric dimethylarginine.

@article{Zhang2008DetrimentalEO,
  title={Detrimental effects of nicotine on the acute gastric mucosal injury induced by ethanol: role of asymmetric dimethylarginine.},
  author={Zhe Zhang and Yuan Zhou and Yi-you Zou and Li Wang and Zhi-Chun Yang and Ren Yong Guo and Dai Li Rong-sheng Li and Jun Peng and Yuanjian Li},
  journal={Canadian journal of physiology and pharmacology},
  year={2008},
  volume={86 12},
  pages={
          835-40
        }
}
The aim of this study was to determine whether asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is responsible for the detrimental effects of nicotine on ethanol-induced gastric mucosal injury and its underlying mechanisms. Gastric mucosal injury was induced by an injection of ethanol in the stomach in rats. Animals were pretreated with nicotine for 28 days before ethanol injection. The gastric mucosal ulcer index (UI) and the levels of ADMA and NO in… CONTINUE READING