Detrimental effects of mannose-binding lectin (MBL2) promoter genotype XA/XA on HIV-1 vertical transmission and AIDS progression.

@article{Mangano2008DetrimentalEO,
  title={Detrimental effects of mannose-binding lectin (MBL2) promoter genotype XA/XA on HIV-1 vertical transmission and AIDS progression.},
  author={Andrea M Mangano and Carlos Rocco and Stefano M. Marino and D{\'e}bora Mecikovsky and Fernanda Genre and Paula C Aulicino and Rosa Bologna and Luisa Sen},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={198 5},
  pages={694-700}
}
BACKGROUND The literature on the involvement of mannose-binding lectin (MBL) in human immunodeficiency virus (HIV) transmission and acquired immunodeficiency syndrome (AIDS) is conflicting. Polymorphisms in the MBL2 gene reduce the level of protein and alter its structure. Thus, we investigated whether MBL2 alleles and plasma concentrations of MBL are associated with perinatal HIV transmission and disease progression. METHODS Frequencies of MBL2 allelic variants (B, C, D, and X) were… CONTINUE READING