Detrimental effects of chronic hypothalamic—pituitary—adrenal axis activation

  title={Detrimental effects of chronic hypothalamic—pituitary—adrenal axis activation},
  author={Jacob Raber},
  journal={Molecular Neurobiology},
Increasing evidence suggests that the detrimental effects of glucocorticoid (GC) hypersecretion occur by activation of the hypothalamic-pituitary-adrenal (HPA) axis in several human pathologies, including obesity, Alzheimer's disease, AIDS dementia, and depression. The different patterns of response by the HPA axis during chronic activation are an important consideration in selecting an animal model to assess HPA axis function in a particular disorder. This article will discuss how chronic HPA… CONTINUE READING


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