Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice

@inproceedings{Leboucher2013DetrimentalEO,
  title={Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice},
  author={Antoine Leboucher and Cyril Laurent and Francisco-Jos{\'e} Fernandez-Gomez and Sylvie Burnouf and Laetitia Troquier and Sabiha Eddarkaoui and Dominique Demeyer and Rapha{\"e}lle Caillierez and Nad{\`e}ge Zommer and Emmanuelle Vallez and Kadiombo Bantubungi and Christophe Breton and Pascal Pigny and Val{\'e}rie Bu{\'e}e-Scherrer and Bart Staels and Malika Hamdane and Anne Tailleux and Luc Bu{\'e}e and David Blum},
  booktitle={Diabetes},
  year={2013}
}
The τ pathology found in Alzheimer disease (AD) is crucial in cognitive decline. Midlife development of obesity, a major risk factor of insulin resistance and type 2 diabetes, increases the risk of dementia and AD later in life. The impact of obesity on AD risk has been suggested to be related to central insulin resistance, secondary to peripheral insulin resistance. The effects of diet-induced obesity (DIO) on τ pathology remain unknown. In this study, we evaluated effects of a high-fat diet… CONTINUE READING

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